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Test Code ADMAB ADAMTS 13 Antibody, Plasma


Ordering Guidance


Consider ordering in patients to aid in distinguishing between congenital thrombotic thrombocytopenic purpura (TTP) and acquired autoimmune TTP.



Specimen Required


Patient Preparation:

Fasting: 8 hours, preferred

Collection Container/Tube: Light-blue top (3.2% sodium citrate)

Submission Container/Tube: Polypropylene plastic vial

Specimen Volume: 1 mL plasma

Collection Instructions:

1. Specimen must be collected prior to replacement therapy.

2. For complete instructions, see Coagulation Guidelines for Specimen Handling and Processing.

3. Centrifuge, transfer all plasma into a plastic vial, and centrifuge plasma again.

4. Aliquot plasma into a separate plastic vial, leaving 0.25 mL in the bottom of centrifuged vial.

5. Freeze plasma immediately (no longer than 4 hours after collection) at -20° C or, ideally, below -40° C.

Specimen Stability Information: Frozen 21 months

Additional Information:

1. Double-centrifuged specimen is critical for accurate results.

2. Each coagulation assay requested should have its own vial.


Forms

If not ordering electronically, complete, print, and send a Coagulation Test Request (T753) with the specimen.

Useful For

Assisting with the diagnosis and monitoring of congenital, immune, or acquired thrombotic thrombocytopenic purpura

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

ADAMTS 13 Antibody, P

Specimen Type

Plasma Na Cit

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma Na Cit Frozen

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values

Negative: <12 U/mL

Borderline positive: 12-15 U/mL

Positive: >15 U/mL

Day(s) Performed

Varies

Report Available

7 to 15 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83520

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ADMAB ADAMTS 13 Antibody, P 40824-5

 

Result ID Test Result Name Result LOINC Value
623136 ADAMTS 13 Antibody 40824-5
623272 Interpretation 69049-5